CLINICAL
Sieving PA, Caruso RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR and Bush RA. CNTF for Human Retinal Neurodegeneration: Phase I Trial of Ciliary Neurotrophic Factor Delivered by Encapsulated Cell Intraocular Implants for Retinitis Pigmentosa. Proc Natl Acad Sci USA, March 7, 2006, vol. 103 no. 10.
Aebischer P, Schluep M, Deglon N, Joseph JM, Hirt L, Heyd B, Goddard M, Hammang JP, Zurn AD, Kato AC, Regli F and Baetge EE. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat Med 2(6):696-9. 1996.
Aebischer P, Pochon NA, Heyd B, Deglon N, Joseph JM, Zurn AD, Baetge EE, Hammang JP, Goddard M, Lysaght M, Kaplan F, Kato AC, Schluep M, Hirt L, Regli F, Porchet F and De Tribolet N. Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. Hum Gene Ther 1;7(7):851-60. 1996.
PRECLINICAL
Zeiss CJ, Allore HG, Towle V and Tao W. CNTF induces dose-dependent alterations in retinal morphology in normal and rcd1 canine retina. Exp Eye Res. 2006 Mar;82(3):395-404.
Bush RA, Lei B, Tao W, Raz D, Chan CC, Cox TA, Santos-Muffley M and Sieving PA. Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: Dose-dependent effect on ERG and retinal histology. IOVS, Vol. 45 (7) 2420-2430. 2004.
Thanos CG, Bell WJ, O’Rourke P, Kauper K, Sherman S, Stabila P and Tao W. Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device. Tissue Engineering, Vol. 10 (11/12):1617-1622. 2004.
Song Y, Zhao L, Tao W, Laties AM, Luo Z and Wen R. Photoreceptor protection by cardiotrophin-1 in transgenic rats with the rhodopsin mutation s334ter. IOVS, 44(9):4069-75. 2003.
Tao W, Wen R, Goddard MB, Sherman S, O’Rourke PJ, Stabila PF, Bell WJ, Dean BJ, Kauper KA, Budz VA, Tsiaras WG, Acland GM, Pearce-Kelling S, Laties AM and Aguirre GD. Encapsulated Cell-Based Delivery of CNTF Reduces Photoreceptor Degeneration in Animal Models of Retinitis Pigmentosa. IOVS, Vol. 43 (10) 3292-3298. 2002.
Hoane MR, Puri KD, Xu L, Stabila PF, Zhao H, Gulwadi AG, Phillips HS, Devaux B, Lindner MD and Tao W. Mammalian-cell-produced neurturin (NTN) is more potent than purified Escherichia coli-produced NTN. Exp Neurol 162(1):189-93. 2000.
Hoane MR, Gulwadi AG, Morrison S, Hovanesian G, Lindner MD and Tao W. Differential in vivo effects of neurturin and glial cell-line-derived neurotrophic factor. Exp Neurol 160(1):235-43. 1999.
Tseng J L, Bruhn SL, Zurn AD, and Aebischer P. Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy. Neuroreport 9:1817. 1998.
Sautter J, Tseng JL, Braguglia D, Aebischer P, Spenger C, Seiler RW, Widmer HR and Zurn AD. Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic graft. Exp Neurol 149:230. 1998.
Emerich DF, Cain CK, Greco C, Saydoff JA, Hu ZY, Liu H and Lindner MD. Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease. Cell Transplant 6:249. 1997.
Emerich DF, Winn SR, Hantraye PM, Peschanski M, Chen EY, Chu Y, McDermott P, Baetge EE and Kordower JH. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature 386:395. 1997.
Tseng JL, Baetge EE, Zurn A D, and Aebischer P. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. J Neurosci 17:325. 1997.
Emerich DF, Lindner MD, Winn SR, Chen EY, Frydel BR and Kordower JH. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J Neurosci 16:5168. 1996.
Emerich DF, Plone M, Francis J, Frydel BR, Winn SR and Lindner MD. Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts. Brain Res 736:99. 1996.
Kordower JH, Chen EY, Mufson EJ, Winn SR, and DF Emerich. Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: trophic effects upon cholinergic and noncholinergic striatal neurons. Neuroscience 72:63. 1996.
Lindner MD, Winn SR, Baetge EE, Hammang JP, Gentile FT, Doherty E, McDermott PE, Frydel B, Ullman MD, Schallert T and et al. Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms. Exp Neurol 132:62. 1995.
Sagot Y, Tan SA, Baetge E, Schmalbruch H, Kato AC and Aebischer P. Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse. Eur J Neurosci 7:1313. 1995.
Winn SR, Hammang JP, Emerich DF, Lee A, Palmiter RD and Baetge EE. Polymer-encapsulated cells genetically modified to secrete human nerve growth factor promote the survival of axotomized septal cholinergic neurons. Proc Natl Acad Sci USA 91:2324. 1994.
Aebischer P, Buchser E, Joseph JM, Favre J, de Tribolet N, Lysaght M, Rudnick S and Goddard M. Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report. Transplantation 15;58(11):1275-7. 1994.
Emerich DF, Hammang JP, Baetge EE and Winn SR. Implantation of polymer-encapsulated human nerve growth factor- secreting fibroblasts attenuates the behavioral and neuropathological consequences of quinolinic acid injections into rodent striatum. Exp Neurol 130:141. 1994.
Emerich DF, Winn SR, Harper J, Hammang JP, Baetge EE and Kordower JH. Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons. J Comp Neurol 349:148. 1994.
Kordower JH, Winn SR, Liu YT, Mufson EJ, Sladek JR., Hammang JP, Baetge EE and Emerich DF. The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Natl Acad Sci USA 91:10898. 1994.
Stabila PF, Wong SC, Kaplan FA and Tao W. Cell surface expression of a human IgG Fc chimera activates macrophages through Fc receptors. Nat Biotechnol 16(13):1357-60. 1998.
Lysaght M and Aebischer P. Encapsulated cells as therapy. Scientific American 280:76. 1999. |
