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Scientific Publications

Sieving PA, Caruso RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR, and Bush RA. CNTF for Human Retinal Neurodegeneration: Phase I Trial of Ciliary Neurotrophic Factor Delivered by Encapsulated Cell Intraocular Implants for Retinitis Pigmentosa. Proc Natl Acad Sci USA, March 7, 2006, vol. 103 no. 10

Zeiss CJ, Allore HG, Towle V, and Tao W. CNTF induces dose-dependent alterations in retinal morphology in normal and rcd1 canine retina. Exp Eye Res. 2006 Mar;82(3):395-404.

Thanos CG, Bell WJ, O’Rourke P,Kauper K, Sherman S, Stabila P and Tao W. Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device. Tissue Engineering, Vol. 10 (11/12):1617-1622. 2004.

Bush RA, Lei B, Tao W, Raz D, Chan CC, Cox TA, Santos-Muffley M, and Sieving PA. Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: Dose-dependent effect on ERG and retinal histology.IOVS, Vol. 45 (7) 2420-2430. 2004.

Song Y, Zhao L,Tao W,Laties AM, Luo Z, and Wen R. Photoreceptor protection by cardiotrophin-1 in transgenic rats with the rhodopsin mutation s334ter. IOVS, 44(9):4069-75. 2003.

Tao W, Wen R, Goddard MB, Sherman S, O’Rourke PJ, Stabila PF, Bell WJ, Dean BJ, Kauper KA, Budz VA, Tsiaras WG, Acland GM, Pearce-Kelling S, Laties AM, and Aguirre GD Encapsulated Cell-Based Delivery of CNTF Reduces Photoreceptor Degeneration in Animal Models of Retinitis Pigmentosa. IOVS, Vol. 43 (10) 3292-3298. 2002.

Hoane MR, Puri KD, Xu L, Stabila PF, Zhao H, Gulwadi AG, Phillips HS, Devaux B, Lindner MD, Tao W Mammalian-cell-produced neurturin (NTN) is more potent than purified Escherichia coli-produced NTN. Exp Neurol 162(1):189-93. 2000.

Hoane MR, Gulwadi AG, Morrison S, Hovanesian G, Lindner MD, Tao W Differential in vivo effects of neurturin and glial cell-line-derived neurotrophic factor.Exp Neurol 160(1):235-43. 1999.

Lysaght, M., and P. Aebischer. Encapsulated cells as therapy. Scientific American 280:76. 1999.

Stabila PF, Wong SC, Kaplan FA, Tao W Cell surface expression of a human IgG Fc chimera activates macrophages through Fc receptors. Nat Biotechnol 16(13):1357-60. 1998.

Tseng, J. L., S. L. Bruhn, A. D. Zurn, and P. Aebischer. Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy. Neuroreport 9:1817. 1998.

Sautter, J., J. L. Tseng, D. Braguglia, P. Aebischer, C. Spenger, R. W. Seiler, H. R. Widmer, and A. D. Zurn. Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic graft. Exp Neurol 149:230. 1998.

Emerich, D. F., C. K. Cain, C. Greco, J. A. Saydoff, Z. Y. Hu, H. Liu, and M. D. Lindner. Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease. Cell Transplant 6:249. 1997.

Emerich, D. F., S. R. Winn, P. M. Hantraye, M. Peschanski, E. Y. Chen, Y. Chu, P. McDermott, E. E. Baetge, and J. H. Kordower. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature 386:395. 1997.

Tseng, J. L., E. E. Baetge, A. D. Zurn, and P. Aebischer. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. J Neurosci 17:325. 1997.

Aebischer P, Schluep M, Deglon N, Joseph JM, Hirt L, Heyd B, Goddard M, Hammang JP, Zurn AD, Kato AC, Regli F, Baetge EE Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat Med 2(6):696-9. 1996.

Aebischer P, Pochon NA, Heyd B, Deglon N, Joseph JM, Zurn AD, Baetge EE, Hammang JP, Goddard M, Lysaght M, Kaplan F, Kato AC, Schluep M, Hirt L, Regli F, Porchet F, De Tribolet N Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. Hum Gene Ther 1;7(7):851-60. 1996.

Emerich, D. F., M. D. Lindner, S. R. Winn, E. Y. Chen, B. R. Frydel, and J. H. Kordower. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J Neurosci 16:5168. 1996.

Emerich, D. F., M. Plone, J. Francis, B. R. Frydel, S. R. Winn, and M. D. Lindner. Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts. Brain Res 736:99. 1996.

Kordower, J. H., E. Y. Chen, E. J. Mufson, S. R. Winn, and D. F. Emerich. Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: trophic effects upon cholinergic and noncholinergic striatal neurons. Neuroscience 72:63. 1996.

Lindner, M. D., S. R. Winn, E. E. Baetge, J. P. Hammang, F. T. Gentile, E. Doherty, P. E. McDermott, B. Frydel, M. D. Ullman, T. Schallert, and et al. Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms. Exp Neurol 132:62. 1995.

Sagot, Y., S. A. Tan, E. Baetge, H. Schmalbruch, A. C. Kato, and P. Aebischer. Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse. Eur J Neurosci 7:1313. 1995.

Winn, S. R., J. P. Hammang, D. F. Emerich, A. Lee, R. D. Palmiter, and E. E. Baetge. Polymer-encapsulated cells genetically modified to secrete human nerve growth factor promote the survival of axotomized septal cholinergic neurons. Proc Natl Acad Sci U S A 91:2324. 1994.

Aebischer P, Buchser E, Joseph JM, Favre J, de Tribolet N, Lysaght M, Rudnick S, Goddard M Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report. Transplantation 15;58(11):1275-7. 1994.

Emerich, D. F., J. P. Hammang, E. E. Baetge, and S. R. Winn. Implantation of polymer-encapsulated human nerve growth factor- secreting fibroblasts attenuates the behavioral and neuropathological consequences of quinolinic acid injections into rodent striatum. Exp Neurol 130:141. 1994.

Emerich, D. F., S. R. Winn, J. Harper, J. P. Hammang, E. E. Baetge, and J. H. Kordower. Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons. J Comp Neurol 349:148. 1994.

Kordower, J. H., S. R. Winn, Y. T. Liu, E. J. Mufson, J. R. Sladek, Jr., J. P. Hammang, E. E. Baetge, and D. F. Emerich. The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Natl Acad Sci U S A 91:10898. 1994.

 



 
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