Scientific Publications




Emily Y. Chew, MD; Traci E. Clemons, PhD; Glenn J. Jaffe, MD; Charles A. Johnson, MD; Sina Farsiu, PhD; Eleonora M. Lad, MD, PhD; Robyn Guymer, MD, PhD; Philip Rosenfeld, MD, PhD; Jean-Pierre Hubschman, MD; Ian Constable, MD; Henry Wiley, MD; Lawrence J. Singerman, MD; Mark Gillies, MD, PhD; Grant Comer, MD; Barbara Blodi, MD; Dean Eliott, MD; Jiong Yan, MD; Alan Bird, MD; Martin Friedlander, MD, PhD. Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2. Ophthalmology. 2018.


Kauper K, McGovern C, Sherman S, Heatherton P, Rapoza R, Stabila P, Dean B, Lee A, Borges S, Bouchard B and Tao W Two-Year Intraocular Delivery of Ciliary Neurotrophic Factor by Encapsulated Cell Technology Implants in Patients with Chronic Retinal Degenerative Diseases . Invest Ophthalmol Vis Sci. 53(12):7484-7491. 2012


Talcott KE, Ratnam K, Sundquist SM, Lucero AS, Lujan BJ, Tao W, Porco TC, Roorda A, and Duncan JL. Longitudinal study of cone photoreceptors during retinal degeneration and inresponse to ciliary neurotrophic factor treatment. Invest Ophthalmol Vis Sci. 52(5):2219-26. 2011


Zhang K, Hopkins JJ, Heier JS, Birch DG, Halperin LS, Albini TA, Brown DM, Jaffe GJ, Tao W, and Williams GA. Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. Proc Natl Acad Sci USA. 108(15):6241-5. 2011


Sieving PA, Caruso RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR and Bush RA. CNTF for Human Retinal Neurodegeneration: Phase I Trial of Ciliary Neurotrophic Factor Delivered by Encapsulated Cell Intraocular Implants for Retinitis Pigmentosa. Proc Natl Acad Sci USA 103 (10): 3896-901. 2006




Zeiss CJ, Allore HG, Towle V and Tao W. CNTF induces dose-dependent alterations in retinal morphology in normal and rcd1 canine retina. Exp Eye Res. 2006 Mar;82(3):395-404.


Bush RA, Lei B, Tao W, Raz D, Chan CC, Cox TA, Santos-Muffley M and Sieving PA. Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: Dose-dependent effect on ERG and retinal histology. IOVS, Vol. 45 (7) 2420-2430. 2004.


Thanos CG, Bell WJ, O'Rourke P, Kauper K, Sherman S, Stabila P and Tao W. Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device. Tissue Engineering, Vol. 10 (11/12):1617-1622. 2004.


Tao W, Wen R, Goddard MB, Sherman S, O'Rourke PJ, Stabila PF, Bell WJ, Dean BJ, Kauper KA, Budz VA, Tsiaras WG, Acland GM, Pearce-Kelling S, Laties AM and Aguirre GD. Encapsulated Cell-Based Delivery of CNTF Reduces Photoreceptor Degeneration in Animal Models of Retinitis Pigmentosa. IOVS, Vol. 43 (10) 3292-3298. 2002.



Wen R, Tao W, Li Y, and Sieving PA. CNTF and retina. Prog Retin Eye Res. (2):136-51. 2012


Tao W. Application of encapsulated cell technology for retinal degenerative diseases. Expert Opin Biol Ther. 6(7):717-26. 2006


Lysaght M and Aebischer P. Encapsulated cells as therapy. Scientific American 280:76. 1999



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